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Does Aspirin Prevent Erectile Dysfunction?

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Although aspirin is sometimes touted as a treatment for ED, this claim is currently not supported by the evidence.

Aspirin belongs to a class of drugs called Nonsteroidal anti-inflammatory drugs (NSAIDS). A 2011 study1 found that “regular nonsteroidal anti-inflammatory drug use is associated with erectile dysfunction beyond what would be expected due to age and comorbidity.” In other words, aspirin might actually increase erectile dysfunction.

Another study2 conducted in 2015 for a mild association between NSAID use and erectile dysfunction, but concluded that “The modest associations of NSAID use with ED risk in the present cohort were probably attributable to confounding indications for NSAID use. NSAID use was not associated with ED risk.”

A 2019 study3 conducted on rats found that long-term aspirin use had no effect on erectile dysfunction. (Rats have a psysiology that is similar to humans, so they are often used for drug trials.)

On the other hand, a 2020 meta-analysis4 (a compilation of other studies) concluded that “erectile function is significantly improved by the intervention of aspirin compared to the placebo group.” However, the analysis also stated that “The availability of a few RCTs [studies]suggests there is a need for further trials on the efficacy of aspirin for vasculogenic ED in men in comparison to the placebo group in double-blinded RCTs.”

Conclusion

There is currently no conclusive evidence that aspirin has a significant effect on erectile dysfunction.




References

  1. Gleason, Joseph M; Slezak, Jeffrey M; Jung, Howard; Reynolds, Kristi; Van Den Eeden, Stephen K; Haque, Reina; Quinn, Virginia P; Loo, Ronald K; Jacobsen, Steven J. “Regular Nonsteroidal Anti-Inflammatory Drug Use and Erectile Dysfunction.” The Journal of Urology. April 2011. <https://www.auajournals.org/doi/full/10.1016/j.juro.2010.11.092>
  2. Patel, Darshan P; Schenk, Jeannette M; Darke, Amy; Myers, Jeremy B; Brant, William O; Hotaling, James M. “Non-steroidal anti-inflammatory drug (NSAID) use is not associated with erectile dysfunction risk: results from the Prostate Cancer Prevention Trial.” BJU International. March 2016;117(3):500-6.
    <https://pubmed.ncbi.nlm.nih.gov/26305866/>
  3. Li, Tao; Wu, Changjing; Fu, Fudong; Xiong, Wenfeng; Qin, Feng; Yuan, Jiuhong. “Long-Term Aspirin Administration Has No Effect on Erectile Function: Evidence from Adult Rats and Ageing Rat Model.” Scientific Reports. May 2019.
    <https://www.nature.com/articles/s41598-019-44386-x>
  4. Irfan, Muhammad; Ismail, Shaiful Bahari; Noor, Norhayati Mohd;
    < Hussain, Nik Hazlina Nik. “Efficacy of Aspirin for Vasculogenic Erectile Dysfunction in Men: A Meta-Analysis of Randomized Control Trials.” American Journal of Men’s Health. September-October 2020.
    <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607788/>

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